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KMID : 0882420170920010079
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Korean Journal of Medicine
2017 Volume.92 No. 1 p.79 ~ p.83
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A Case of Myeloid Neoplasm with a PDGFRB Rearrangement and Eosinophilia
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Cho Nam-Gil
Kim Dae-Jin
Shim Min-Jung
Chong So-Young
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Abstract
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Myeloid neoplasia with eosinophilia and platelet-derived growth factor receptor beta (PDGFRB) rearrangements is an uncommon Philadelphia-negative myeloproliferative neoplasm. Their most common morphological diagnosis is chronic myelomonocytic leukemia with eosinophilia, which is associated with t(5;12)(q33;p13) and results in the formation of the ETV6-PDGFRB fusion gene.
Here, we report a 49-year-old man with a myeloid neoplasm with a PDGFRB rearrangement, who was incidentally diagnosed with hyperleukocytosis and eosinophilia during a health screening. A chromosome analysis of a bone marrow sample revealed 46, XY, t(5;12)(q33;p13), and fluorescence in situ hybridization analysis revealed the PDGFRB gene rearrangement. The patient was treated with imatinib and subsequently achieved complete hematological and molecular remission.
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KEYWORD
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Myeloproliferative disorder, PDGFRB, Eosinophilia, Imatinib mesylate
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